Drug interactions
Bupropion + Lemborexant
Severity: Minor
Bupropion and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant may weakly induce CYP2B6, potentially lowering bupropion exposure, and it adds some somnolence and next-day impairment. The combined effect is usually small and manageable.
What this interaction means in plain words
Bupropion and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP2B6 induction by lemborexant, plus additive CNS effects.
What to do
Monitor bupropion response and adjust dose if efficacy falls. Counsel about next-day drowsiness and driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Bupropion with Lemborexant?
MediHelp rates the interaction as minor. Bupropion and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lemborexant may weakly induce CYP2B6, potentially lowering bupropion exposure, and it adds some somnolence and next-day impairment. The combined effect is usually small and manageable.
How serious is the interaction between Bupropion and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bupropion response and adjust dose if efficacy falls. Counsel about next-day drowsiness and driving.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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