Drug interactions
Bupropion + Memantine-donepezil
Severity: Minor
Bupropion and Memantine-donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and may raise donepezil concentrations. Higher exposure could increase cholinergic effects such as nausea, bradycardia and vomiting, although the clinical effect is usually modest.
What this interaction means in plain words
Bupropion and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Bupropion inhibits CYP2D6, one of the two main pathways of donepezil metabolism.
What to do
No routine dose change is needed; monitor for gastrointestinal effects and bradycardia when bupropion is started or the dose is increased.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Memantine-donepezil?
MediHelp rates the interaction as minor. Bupropion and Memantine-donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion is a strong CYP2D6 inhibitor and may raise donepezil concentrations. Higher exposure could increase cholinergic effects such as nausea, bradycardia and vomiting, although the clinical effect is usually modest.
How serious is the interaction between Bupropion and Memantine-donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for gastrointestinal effects and bradycardia when bupropion is started or the dose is increased.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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