Drug interactions
Bupropion + Mifepristone
Severity: Moderate
Bupropion and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone has been reported to inhibit CYP2B6, the enzyme that converts bupropion to hydroxybupropion. This may raise bupropion exposure and its dose-related adverse effects, including seizure risk, while lowering active metabolite formation.
What this interaction means in plain words
Bupropion and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP2B6 by mifepristone reduces bupropion hydroxylation.
What to do
Monitor for bupropion adverse effects such as insomnia, agitation and seizures, and use the lowest effective bupropion dose during mifepristone therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Bupropion with Mifepristone?
MediHelp rates the interaction as moderate. Bupropion and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone has been reported to inhibit CYP2B6, the enzyme that converts bupropion to hydroxybupropion. This may raise bupropion exposure and its dose-related adverse effects, including seizure risk, while lowering active metabolite formation.
How serious is the interaction between Bupropion and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bupropion adverse effects such as insomnia, agitation and seizures, and use the lowest effective bupropion dose during mifepristone therapy.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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