Drug interactions
Bupropion + Milnacipran
Severity: Moderate
Bupropion and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise noradrenergic activity and can increase blood pressure and heart rate. Bupropion also lowers the seizure threshold and inhibits CYP2D6. Combined use may increase the risk of seizures and cardiovascular effects.
What this interaction means in plain words
Bupropion and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Milnacipran belongs to Central Nervous System.
Why it happens
Additive noradrenergic stimulation and seizure-threshold lowering.
What to do
Use the lowest effective doses and monitor blood pressure and heart rate. Watch for seizures and agitation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Bupropion with Milnacipran?
MediHelp rates the interaction as moderate. Bupropion and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs raise noradrenergic activity and can increase blood pressure and heart rate. Bupropion also lowers the seizure threshold and inhibits CYP2D6. Combined use may increase the risk of seizures and cardiovascular effects.
How serious is the interaction between Bupropion and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor blood pressure and heart rate. Watch for seizures and agitation.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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