Drug interactions
Bupropion + Nebivolol
Severity: Moderate
Bupropion and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is extensively metabolized by CYP2D6, and bupropion inhibition can increase concentrations of the active parent drug. This may cause bradycardia, hypotension and fatigue.
What this interaction means in plain words
Bupropion and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Nebivolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated nebivolol metabolism by bupropion.
What to do
Monitor heart rate and blood pressure when bupropion is started or stopped, and reduce the nebivolol dose if excessive beta-blockade occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Bupropion with Nebivolol?
MediHelp rates the interaction as moderate. Bupropion and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is extensively metabolized by CYP2D6, and bupropion inhibition can increase concentrations of the active parent drug. This may cause bradycardia, hypotension and fatigue.
How serious is the interaction between Bupropion and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when bupropion is started or stopped, and reduce the nebivolol dose if excessive beta-blockade occurs.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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