Drug interactions
Bupropion + Oliceridine
Severity: Moderate
Bupropion and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion strongly inhibits CYP2D6, which is one pathway of oliceridine metabolism, so opioid exposure and effects may increase. This can heighten sedation and respiratory depression, and stopping bupropion later may reduce opioid effect.
What this interaction means in plain words
Bupropion and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
CYP2D6 inhibition by bupropion reduces oliceridine clearance.
What to do
Monitor for sedation and respiratory depression and give oliceridine less frequently or at lower doses as needed. Re-titrate if bupropion is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Bupropion with Oliceridine?
MediHelp rates the interaction as moderate. Bupropion and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion strongly inhibits CYP2D6, which is one pathway of oliceridine metabolism, so opioid exposure and effects may increase. This can heighten sedation and respiratory depression, and stopping bupropion later may reduce opioid effect.
How serious is the interaction between Bupropion and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and give oliceridine less frequently or at lower doses as needed. Re-titrate if bupropion is discontinued.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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