Drug interactions
Bupropion + Pivmecillinam
Severity: Minor
Bupropion and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pivmecillinam releases pivalate and can cause carnitine depletion, and beta-lactams can rarely lower the seizure threshold. Evidence for a meaningful interaction with bupropion is weak.
What this interaction means in plain words
Bupropion and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Theoretical additive seizure-threshold lowering; the mechanism is not established.
What to do
No routine change is needed; for patients with seizure risk factors, use a short pivmecillinam course and monitor for neurological symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Bupropion with Pivmecillinam?
MediHelp rates the interaction as minor. Bupropion and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pivmecillinam releases pivalate and can cause carnitine depletion, and beta-lactams can rarely lower the seizure threshold. Evidence for a meaningful interaction with bupropion is weak.
How serious is the interaction between Bupropion and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; for patients with seizure risk factors, use a short pivmecillinam course and monitor for neurological symptoms.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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