Drug interactions
Bupropion + Saxagliptin-metformin
Severity: Moderate
Bupropion and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may raise metformin exposure by reducing its renal tubular secretion. This can increase metformin effect and adverse effects such as gastrointestinal upset, with a theoretical lactic acidosis risk.
What this interaction means in plain words
Bupropion and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of metformin.
What to do
Monitor glycemic response and metformin tolerability, and review the dose if adverse effects arise. Check renal function periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Bupropion and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may raise metformin exposure by reducing its renal tubular secretion. This can increase metformin effect and adverse effects such as gastrointestinal upset, with a theoretical lactic acidosis risk.
How serious is the interaction between Bupropion and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic response and metformin tolerability, and review the dose if adverse effects arise. Check renal function periodically.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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