Drug interactions
Bupropion + Sparsentan
Severity: Moderate
Bupropion and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2B6, the main enzyme converting bupropion to hydroxybupropion. Bupropion exposure may fall, which can reduce its antidepressant or smoking-cessation efficacy.
What this interaction means in plain words
Bupropion and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
Induction of CYP2B6 by sparsentan increases the metabolic clearance of bupropion.
What to do
Monitor clinical response to bupropion and consider a dose increase within labeled limits if efficacy is lost. Reassess the dose if sparsentan is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Bupropion with Sparsentan?
MediHelp rates the interaction as moderate. Bupropion and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan induces CYP2B6, the main enzyme converting bupropion to hydroxybupropion. Bupropion exposure may fall, which can reduce its antidepressant or smoking-cessation efficacy.
How serious is the interaction between Bupropion and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to bupropion and consider a dose increase within labeled limits if efficacy is lost. Reassess the dose if sparsentan is discontinued.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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