Drug interactions
Bupropion-naltrexone + Desipramine
Severity: Major
Bupropion-naltrexone and Desipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion substantially raises desipramine concentrations, increasing risk of anticholinergic and cardiac toxicity, and both lower seizure threshold.
What this interaction means in plain words
Bupropion-naltrexone and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion-naltrexone belongs to Miscellaneous; Desipramine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion reduces desipramine clearance, with additive lowering of seizure threshold.
What to do
Start desipramine at a low dose, monitor ECG and drug levels, and avoid use in patients with seizure risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Desipramine?
MediHelp rates the interaction as major. Bupropion-naltrexone and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion substantially raises desipramine concentrations, increasing risk of anticholinergic and cardiac toxicity, and both lower seizure threshold.
How serious is the interaction between Bupropion-naltrexone and Desipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start desipramine at a low dose, monitor ECG and drug levels, and avoid use in patients with seizure risk.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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