Drug interactions
Bupropion-naltrexone + Dextromethorphan
Severity: Moderate
Bupropion-naltrexone and Dextromethorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion strongly inhibits CYP2D6, which is the main route of dextromethorphan clearance. Dextromethorphan exposure can rise substantially, increasing the risk of dizziness, sedation, confusion and serotonergic effects, and may cause seizures through bupropion's lowering of seizure threshold.
What this interaction means in plain words
Bupropion-naltrexone and Dextromethorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Dextromethorphan belongs to Respiratory.
Why it happens
Bupropion and its metabolites inhibit CYP2D6, reducing the metabolism of dextromethorphan.
What to do
Monitor for dextromethorphan adverse effects such as dizziness, agitation and serotonergic symptoms, and use the lowest effective dextromethorphan dose. Choose an alternative antitussive if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Dextromethorphan?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Dextromethorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion strongly inhibits CYP2D6, which is the main route of dextromethorphan clearance. Dextromethorphan exposure can rise substantially, increasing the risk of dizziness, sedation, confusion and serotonergic effects, and may cause seizures through bupropion's lowering of seizure threshold.
How serious is the interaction between Bupropion-naltrexone and Dextromethorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dextromethorphan adverse effects such as dizziness, agitation and serotonergic symptoms, and use the lowest effective dextromethorphan dose. Choose an alternative antitussive if symptoms develop.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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