Drug interactions
Bupropion-naltrexone + Gabapentin enacarbil
Severity: Minor
Bupropion-naltrexone and Gabapentin enacarbil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentinoids can cause sedation and respiratory depression, particularly with other CNS-active drugs. Bupropion is typically stimulating, so the sedative interaction is less clear, but dizziness and impaired alertness may still be additive.
What this interaction means in plain words
Bupropion-naltrexone and Gabapentin enacarbil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion-naltrexone belongs to Miscellaneous; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Possible additive CNS effects; not well established for this pair.
What to do
Use the lowest effective doses and monitor for sedation, dizziness and respiratory symptoms, especially in elderly patients or those with lung disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Bupropion-naltrexone with Gabapentin enacarbil?
MediHelp rates the interaction as minor. Bupropion-naltrexone and Gabapentin enacarbil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gabapentinoids can cause sedation and respiratory depression, particularly with other CNS-active drugs. Bupropion is typically stimulating, so the sedative interaction is less clear, but dizziness and impaired alertness may still be additive.
How serious is the interaction between Bupropion-naltrexone and Gabapentin enacarbil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, dizziness and respiratory symptoms, especially in elderly patients or those with lung disease.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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