Drug interactions
Bupropion-naltrexone + Lemborexant
Severity: Minor
Bupropion-naltrexone and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant may modestly induce CYP2B6 and lower bupropion exposure, and both drugs affect CNS function. The result may be reduced bupropion effect and additive somnolence or impaired alertness.
What this interaction means in plain words
Bupropion-naltrexone and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion-naltrexone belongs to Miscellaneous; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP2B6 induction by lemborexant with possible additive CNS effects.
What to do
Monitor bupropion response and adjust the dose if needed. Counsel on daytime drowsiness and driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Bupropion-naltrexone with Lemborexant?
MediHelp rates the interaction as minor. Bupropion-naltrexone and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lemborexant may modestly induce CYP2B6 and lower bupropion exposure, and both drugs affect CNS function. The result may be reduced bupropion effect and additive somnolence or impaired alertness.
How serious is the interaction between Bupropion-naltrexone and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bupropion response and adjust the dose if needed. Counsel on daytime drowsiness and driving.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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