Drug interactions
Bupropion-naltrexone + Milnacipran
Severity: Moderate
Bupropion-naltrexone and Milnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on noradrenergic pathways and can raise blood pressure and heart rate. Both may also lower the seizure threshold, so the combination adds seizure and neuropsychiatric risk.
What this interaction means in plain words
Bupropion-naltrexone and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Milnacipran belongs to Central Nervous System.
Why it happens
Additive noradrenergic effects and additive lowering of the seizure threshold; no clear pharmacokinetic mechanism.
What to do
Avoid in patients with seizure risk factors or uncontrolled hypertension. If used together, keep doses low and monitor blood pressure, heart rate and for seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Milnacipran?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Milnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on noradrenergic pathways and can raise blood pressure and heart rate. Both may also lower the seizure threshold, so the combination adds seizure and neuropsychiatric risk.
How serious is the interaction between Bupropion-naltrexone and Milnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure risk factors or uncontrolled hypertension. If used together, keep doses low and monitor blood pressure, heart rate and for seizures.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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