Drug interactions
Buspirone + Crizotinib
Severity: Moderate
Buspirone and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and can raise buspirone plasma levels because buspirone undergoes extensive CYP3A4 first-pass metabolism. Higher exposure may cause dizziness, nausea, headache and excess sedation.
What this interaction means in plain words
Buspirone and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Crizotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by crizotinib reduces buspirone metabolism.
What to do
Start buspirone at a low dose and titrate to tolerability, monitoring for sedation and dizziness. Reduce the buspirone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Buspirone with Crizotinib?
MediHelp rates the interaction as moderate. Buspirone and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and can raise buspirone plasma levels because buspirone undergoes extensive CYP3A4 first-pass metabolism. Higher exposure may cause dizziness, nausea, headache and excess sedation.
How serious is the interaction between Buspirone and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start buspirone at a low dose and titrate to tolerability, monitoring for sedation and dizziness. Reduce the buspirone dose if adverse effects appear.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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