Drug interactions
Buspirone + Darunavir
Severity: Moderate
Buspirone and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can substantially raise buspirone concentrations. This may cause excessive sedation, dizziness and serotonergic adverse effects.
What this interaction means in plain words
Buspirone and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 metabolism of buspirone, enhanced by the pharmacokinetic booster.
What to do
Begin with a low buspirone dose and titrate carefully while monitoring for sedation and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Buspirone with Darunavir?
MediHelp rates the interaction as moderate. Buspirone and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can substantially raise buspirone concentrations. This may cause excessive sedation, dizziness and serotonergic adverse effects.
How serious is the interaction between Buspirone and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin with a low buspirone dose and titrate carefully while monitoring for sedation and dizziness.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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