Drug interactions
Buspirone + Fosaprepitant
Severity: Minor
Buspirone and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, which is a moderate CYP3A4 inhibitor. A single IV dose causes only a short-lived rise in exposure to CYP3A4 substrates such as buspirone, which may bring on more dizziness, drowsiness or nausea.
What this interaction means in plain words
Buspirone and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buspirone belongs to Central Nervous System; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant temporarily inhibits CYP3A4-mediated first-pass and hepatic metabolism of buspirone.
What to do
No routine dose change is needed for a single fosaprepitant dose. Watch for excess sedation or dizziness and consider reducing the buspirone dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Buspirone with Fosaprepitant?
MediHelp rates the interaction as minor. Buspirone and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, which is a moderate CYP3A4 inhibitor. A single IV dose causes only a short-lived rise in exposure to CYP3A4 substrates such as buspirone, which may bring on more dizziness, drowsiness or nausea.
How serious is the interaction between Buspirone and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for a single fosaprepitant dose. Watch for excess sedation or dizziness and consider reducing the buspirone dose if symptoms occur.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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