Drug interactions
Buspirone + Iloperidone
Severity: Minor
Buspirone and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has weak, time-dependent CYP3A inhibition, which may modestly increase buspirone exposure. Both drugs can also cause dizziness and sedation, so adverse effects may be more pronounced.
What this interaction means in plain words
Buspirone and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buspirone belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Time-dependent inhibition of CYP3A4 by iloperidone reduces buspirone clearance, with additive CNS effects.
What to do
No empirical dose change is required. Monitor for sedation, dizziness and orthostasis, and lower the buspirone dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Buspirone with Iloperidone?
MediHelp rates the interaction as minor. Buspirone and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone has weak, time-dependent CYP3A inhibition, which may modestly increase buspirone exposure. Both drugs can also cause dizziness and sedation, so adverse effects may be more pronounced.
How serious is the interaction between Buspirone and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required. Monitor for sedation, dizziness and orthostasis, and lower the buspirone dose if these occur.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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