Drug interactions
Buspirone + Lasmiditan
Severity: Moderate
Buspirone and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and sedation, and buspirone can do the same. Together they may increase drowsiness and impair driving and psychomotor performance. Lasmiditan is also a 5-HT1F agonist, but serotonin syndrome risk is considered low.
What this interaction means in plain words
Buspirone and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant and sedative effects (pharmacodynamic).
What to do
Counsel patients to avoid driving or hazardous activities for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Buspirone with Lasmiditan?
MediHelp rates the interaction as moderate. Buspirone and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and sedation, and buspirone can do the same. Together they may increase drowsiness and impair driving and psychomotor performance. Lasmiditan is also a 5-HT1F agonist, but serotonin syndrome risk is considered low.
How serious is the interaction between Buspirone and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or hazardous activities for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation and dizziness.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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