Drug interactions
Buspirone + Levomilnacipran
Severity: Moderate
Buspirone and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, so combining them may raise the risk of serotonin syndrome. Symptoms include agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity.
What this interaction means in plain words
Buspirone and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buspirone belongs to Central Nervous System; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from 5-HT1A partial agonism (buspirone) and serotonin-norepinephrine reuptake inhibition (levomilnacipran).
What to do
If combined, use the lowest effective doses and monitor for serotonin syndrome, particularly after dose increases. Stop both and treat if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Buspirone with Levomilnacipran?
MediHelp rates the interaction as moderate. Buspirone and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, so combining them may raise the risk of serotonin syndrome. Symptoms include agitation, tremor, hyperthermia, diarrhea and neuromuscular hyperactivity.
How serious is the interaction between Buspirone and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If combined, use the lowest effective doses and monitor for serotonin syndrome, particularly after dose increases. Stop both and treat if symptoms develop.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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