Drug interactions
Buspirone + Lurasidone
Severity: Minor
Buspirone and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness and dizziness, so taking them together may add to CNS effects and impair alertness. Lurasidone is also CYP3A4 metabolized, but buspirone is not a notable inhibitor, so the interaction is mainly pharmacodynamic.
What this interaction means in plain words
Buspirone and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buspirone belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS effects from buspirone and lurasidone.
What to do
Monitor for sedation, dizziness and impaired alertness, particularly when starting or adjusting doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Buspirone with Lurasidone?
MediHelp rates the interaction as minor. Buspirone and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents can cause drowsiness and dizziness, so taking them together may add to CNS effects and impair alertness. Lurasidone is also CYP3A4 metabolized, but buspirone is not a notable inhibitor, so the interaction is mainly pharmacodynamic.
How serious is the interaction between Buspirone and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and impaired alertness, particularly when starting or adjusting doses.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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