Drug interactions
Buspirone + Tazemetostat
Severity: Minor
Buspirone and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak inducer of CYP3A4, and buspirone is extensively cleared by this enzyme. Concurrent use may lower buspirone exposure and reduce its anxiolytic effect.
What this interaction means in plain words
Buspirone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buspirone belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tazemetostat increases the first-pass and hepatic metabolism of buspirone.
What to do
Monitor for reduced anxiolytic response and increase the buspirone dose gradually if needed. Reassess the dose when tazemetostat is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Buspirone with Tazemetostat?
MediHelp rates the interaction as minor. Buspirone and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak inducer of CYP3A4, and buspirone is extensively cleared by this enzyme. Concurrent use may lower buspirone exposure and reduce its anxiolytic effect.
How serious is the interaction between Buspirone and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced anxiolytic response and increase the buspirone dose gradually if needed. Reassess the dose when tazemetostat is stopped.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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