Drug interactions
Butabarbital + Chlorpromazine
Severity: Moderate
Butabarbital and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, and combined use may cause profound sedation, hypotension, and respiratory depression. Barbiturates also induce hepatic enzymes and may lower chlorpromazine concentrations.
What this interaction means in plain words
Butabarbital and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, plus CYP enzyme induction by the barbiturate that may increase chlorpromazine metabolism.
What to do
Monitor sedation and respiratory status and use the lowest effective doses. Watch for reduced antipsychotic efficacy with prolonged barbiturate use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Butabarbital with Chlorpromazine?
MediHelp rates the interaction as moderate. Butabarbital and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, and combined use may cause profound sedation, hypotension, and respiratory depression. Barbiturates also induce hepatic enzymes and may lower chlorpromazine concentrations.
How serious is the interaction between Butabarbital and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status and use the lowest effective doses. Watch for reduced antipsychotic efficacy with prolonged barbiturate use.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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