Drug interactions
Butabarbital + Lisdexamfetamine
Severity: Moderate
Butabarbital and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a sedative barbiturate while lisdexamfetamine is a stimulant. The stimulant may mask drowsiness without eliminating the barbiturate's impairment of cognition and psychomotor performance. The net effect is unpredictable.
What this interaction means in plain words
Butabarbital and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS pharmacodynamic effects; barbiturate GABA-A potentiation versus amphetamine-mediated catecholamine release.
What to do
Monitor for both oversedation and excessive stimulation, and advise patients that perceived alertness may not reflect actual impairment. Adjust doses based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Butabarbital with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Butabarbital and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a sedative barbiturate while lisdexamfetamine is a stimulant. The stimulant may mask drowsiness without eliminating the barbiturate's impairment of cognition and psychomotor performance. The net effect is unpredictable.
How serious is the interaction between Butabarbital and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for both oversedation and excessive stimulation, and advise patients that perceived alertness may not reflect actual impairment. Adjust doses based on response.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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