Drug interactions
Butabarbital + Montelukast
Severity: Minor
Butabarbital and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic CYP enzymes, including CYP3A4 and CYP2C9, and may lower montelukast concentrations. Reduced effectiveness is possible, particularly with chronic barbiturate use.
What this interaction means in plain words
Butabarbital and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP3A4/CYP2C enzymes increases montelukast clearance.
What to do
Monitor asthma control when butabarbital is started or stopped. Consider adjusting the controller regimen if symptoms worsen.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Butabarbital with Montelukast?
MediHelp rates the interaction as minor. Butabarbital and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic CYP enzymes, including CYP3A4 and CYP2C9, and may lower montelukast concentrations. Reduced effectiveness is possible, particularly with chronic barbiturate use.
How serious is the interaction between Butabarbital and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control when butabarbital is started or stopped. Consider adjusting the controller regimen if symptoms worsen.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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