Drug interactions
Deferasirox + Montelukast
Severity: Moderate
Deferasirox and Montelukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce some CYP enzymes and inhibit CYP2C8, so its net effect on montelukast is uncertain. Reduced or increased montelukast exposure is theoretically possible.
What this interaction means in plain words
Deferasirox and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Montelukast belongs to Respiratory.
Why it happens
Deferasirox modulates CYP3A4 and CYP2C8 activity, which may alter montelukast clearance; the net effect is not well established.
What to do
Monitor asthma control and adverse effects when the combination is started or stopped. Adjust other controller therapy if symptoms worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
- Mitotane + Montelukast Moderate
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Montelukast?
MediHelp rates the interaction as moderate. Deferasirox and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce some CYP enzymes and inhibit CYP2C8, so its net effect on montelukast is uncertain. Reduced or increased montelukast exposure is theoretically possible.
How serious is the interaction between Deferasirox and Montelukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control and adverse effects when the combination is started or stopped. Adjust other controller therapy if symptoms worsen.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Montelukast page.
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