Drug interactions
Enzalutamide + Montelukast
Severity: Moderate
Enzalutamide and Montelukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and a moderate CYP2C8 inducer, and may lower montelukast exposure. This could reduce control of asthma or allergic symptoms.
What this interaction means in plain words
Enzalutamide and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Montelukast belongs to Respiratory.
Why it happens
Enzalutamide induces CYP3A4 and CYP2C8, increasing montelukast metabolism.
What to do
Monitor asthma control and consider additional controller therapy if symptoms worsen. Reassess response after enzalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
- Mitotane + Montelukast Moderate
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Montelukast?
MediHelp rates the interaction as moderate. Enzalutamide and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and a moderate CYP2C8 inducer, and may lower montelukast exposure. This could reduce control of asthma or allergic symptoms.
How serious is the interaction between Enzalutamide and Montelukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control and consider additional controller therapy if symptoms worsen. Reassess response after enzalutamide is stopped.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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