Drug interactions
Carbamazepine + Montelukast
Severity: Moderate
Carbamazepine and Montelukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces hepatic enzymes, including CYP3A4 and CYP2C8/2C9, and may lower montelukast plasma levels. This could reduce control of asthma or allergic rhinitis.
What this interaction means in plain words
Carbamazepine and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Montelukast belongs to Respiratory.
Why it happens
Enzyme induction by carbamazepine increases montelukast metabolism.
What to do
Monitor asthma control and symptoms after starting or stopping carbamazepine. Consider optimizing other controller therapy if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
- Mitotane + Montelukast Moderate
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Montelukast?
MediHelp rates the interaction as moderate. Carbamazepine and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces hepatic enzymes, including CYP3A4 and CYP2C8/2C9, and may lower montelukast plasma levels. This could reduce control of asthma or allergic rhinitis.
How serious is the interaction between Carbamazepine and Montelukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control and symptoms after starting or stopping carbamazepine. Consider optimizing other controller therapy if response is lost.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Deferasirox, Enzalutamide. The full list is on the Montelukast page.
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