Drug interactions
Apalutamide + Montelukast
Severity: Moderate
Apalutamide and Montelukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer of CYP3A4 and CYP2C8 and may lower montelukast concentrations, since montelukast is metabolized by CYP2C8, 3A4 and 2C9. This could reduce asthma or allergic rhinitis control.
What this interaction means in plain words
Apalutamide and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Montelukast belongs to Respiratory.
Why it happens
Apalutamide induces hepatic CYP enzymes, increasing montelukast clearance.
What to do
Monitor asthma control and symptoms when apalutamide is started. Adjust asthma therapy or add other controllers if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Montelukast
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
- Mitotane + Montelukast Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Montelukast?
MediHelp rates the interaction as moderate. Apalutamide and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong inducer of CYP3A4 and CYP2C8 and may lower montelukast concentrations, since montelukast is metabolized by CYP2C8, 3A4 and 2C9. This could reduce asthma or allergic rhinitis control.
How serious is the interaction between Apalutamide and Montelukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control and symptoms when apalutamide is started. Adjust asthma therapy or add other controllers if control is lost.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Carbamazepine, Deferasirox, Enzalutamide. The full list is on the Montelukast page.
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