Drug interactions
Butalbital + Chlorpromazine
Severity: Moderate
Butalbital and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, and combined use may increase drowsiness, dizziness, hypotension, and respiratory depression. Butalbital may also modestly lower chlorpromazine levels through enzyme induction.
What this interaction means in plain words
Butalbital and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, plus possible hepatic enzyme induction by the barbiturate.
What to do
Counsel patients about sedation and avoid alcohol or other depressants. Monitor alertness and blood pressure and limit butalbital use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Butalbital with Chlorpromazine?
MediHelp rates the interaction as moderate. Butalbital and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, and combined use may increase drowsiness, dizziness, hypotension, and respiratory depression. Butalbital may also modestly lower chlorpromazine levels through enzyme induction.
How serious is the interaction between Butalbital and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about sedation and avoid alcohol or other depressants. Monitor alertness and blood pressure and limit butalbital use.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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