Drug interactions
Butalbital + Dutasteride
Severity: Minor
Butalbital and Dutasteride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with possible CYP3A4 inducing activity that might lower dutasteride levels. Intermittent use makes a meaningful effect unlikely.
What this interaction means in plain words
Butalbital and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 induction by butalbital increasing dutasteride metabolism.
What to do
No dose adjustment is needed. Reassess dutasteride efficacy only if frequent chronic butalbital use is accompanied by loss of response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Frequently asked questions
Can I take Butalbital with Dutasteride?
MediHelp rates the interaction as minor. Butalbital and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate with possible CYP3A4 inducing activity that might lower dutasteride levels. Intermittent use makes a meaningful effect unlikely.
How serious is the interaction between Butalbital and Dutasteride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Reassess dutasteride efficacy only if frequent chronic butalbital use is accompanied by loss of response.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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