Drug interactions
Dutasteride + Levoketoconazole
Severity: Moderate
Dutasteride and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may increase dutasteride exposure. Dutasteride's wide safety margin makes serious harm unlikely, but adverse effects may be more frequent.
What this interaction means in plain words
Dutasteride and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride belongs to Genitourinary; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition by levoketoconazole decreases dutasteride clearance.
What to do
Monitor for sexual and breast-related adverse effects; reassess the need for dutasteride if levoketoconazole is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
- Artemether / lumefantrine + Dutasteride Minor
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Dutasteride with Levoketoconazole?
MediHelp rates the interaction as moderate. Dutasteride and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may increase dutasteride exposure. Dutasteride's wide safety margin makes serious harm unlikely, but adverse effects may be more frequent.
How serious is the interaction between Dutasteride and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sexual and breast-related adverse effects; reassess the need for dutasteride if levoketoconazole is prolonged.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Nefazodone, Rifampin, St john's wort. The full list is on the Dutasteride page.
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