Drug interactions
Amobarbital + Dutasteride
Severity: Minor
Amobarbital and Dutasteride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital is a CYP3A4 inducer and could lower dutasteride concentrations. Dutasteride has a very long half-life and the clinical effect of any reduction is uncertain.
What this interaction means in plain words
Amobarbital and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amobarbital belongs to Central Nervous System; Dutasteride belongs to Genitourinary.
Why it happens
Barbiturate-mediated CYP3A4 induction increases dutasteride metabolism.
What to do
No dose change is needed. Reassess symptom response if barbiturate therapy is long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Aprepitant + Dutasteride Minor
- Artemether / lumefantrine + Dutasteride Minor
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Frequently asked questions
Can I take Amobarbital with Dutasteride?
MediHelp rates the interaction as minor. Amobarbital and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amobarbital is a CYP3A4 inducer and could lower dutasteride concentrations. Dutasteride has a very long half-life and the clinical effect of any reduction is uncertain.
How serious is the interaction between Amobarbital and Dutasteride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Reassess symptom response if barbiturate therapy is long term.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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