Drug interactions
Dutasteride + Rifampin
Severity: Moderate
Dutasteride and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces CYP3A4 and may lower dutasteride concentrations, possibly reducing its effectiveness. Dutasteride's long half-life may blunt the effect of short rifampin courses.
What this interaction means in plain words
Dutasteride and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP3A4, increasing dutasteride clearance.
What to do
Monitor prostate symptoms and PSA response during prolonged rifampin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
- Artemether / lumefantrine + Dutasteride Minor
Frequently asked questions
Can I take Dutasteride with Rifampin?
MediHelp rates the interaction as moderate. Dutasteride and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces CYP3A4 and may lower dutasteride concentrations, possibly reducing its effectiveness. Dutasteride's long half-life may blunt the effect of short rifampin courses.
How serious is the interaction between Dutasteride and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor prostate symptoms and PSA response during prolonged rifampin therapy.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, St john's wort. The full list is on the Dutasteride page.
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