Drug interactions
Dutasteride + Nefazodone
Severity: Moderate
Dutasteride and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone strongly inhibits CYP3A4 and may raise dutasteride levels. The effect is likely limited to more frequent dose-related adverse effects.
What this interaction means in plain words
Dutasteride and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4-mediated metabolism of dutasteride.
What to do
Monitor for adverse effects such as sexual dysfunction; no routine dose change is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
- Artemether / lumefantrine + Dutasteride Minor
Frequently asked questions
Can I take Dutasteride with Nefazodone?
MediHelp rates the interaction as moderate. Dutasteride and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone strongly inhibits CYP3A4 and may raise dutasteride levels. The effect is likely limited to more frequent dose-related adverse effects.
How serious is the interaction between Dutasteride and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as sexual dysfunction; no routine dose change is required.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Rifampin, St john's wort. The full list is on the Dutasteride page.
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