Drug interactions
Aprepitant + Dutasteride
Severity: Minor
Aprepitant and Dutasteride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dutasteride is metabolised by CYP3A4 and aprepitant may raise its levels. Dutasteride has a wide safety margin and a long half-life, so the change is unlikely to matter.
What this interaction means in plain words
Aprepitant and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Dutasteride belongs to Genitourinary.
Why it happens
Aprepitant inhibits CYP3A4, reducing dutasteride clearance.
What to do
No action is generally needed beyond awareness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Artemether / lumefantrine + Dutasteride Minor
Frequently asked questions
Can I take Aprepitant with Dutasteride?
MediHelp rates the interaction as minor. Aprepitant and Dutasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dutasteride is metabolised by CYP3A4 and aprepitant may raise its levels. Dutasteride has a wide safety margin and a long half-life, so the change is unlikely to matter.
How serious is the interaction between Aprepitant and Dutasteride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed beyond awareness.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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