Drug interactions
Butalbital + Metoclopramide
Severity: Moderate
Butalbital and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that causes sedation, and metoclopramide can also cause drowsiness, so the combined effect on alertness may be additive. The clinical consequence is usually manageable.
What this interaction means in plain words
Butalbital and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive drowsiness and use the lowest effective dose of each drug. Advise the patient to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Butalbital with Metoclopramide?
MediHelp rates the interaction as moderate. Butalbital and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that causes sedation, and metoclopramide can also cause drowsiness, so the combined effect on alertness may be additive. The clinical consequence is usually manageable.
How serious is the interaction between Butalbital and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and use the lowest effective dose of each drug. Advise the patient to avoid driving and alcohol.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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