Drug interactions
Butalbital + Montelukast
Severity: Minor
Butalbital and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with enzyme-inducing properties and may lower montelukast exposure with repeated use. Intermittent use is unlikely to matter, but frequent use may reduce efficacy.
What this interaction means in plain words
Butalbital and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP3A4/CYP2C enzymes increases montelukast clearance.
What to do
Monitor asthma symptom control in patients using butalbital regularly. Adjust controller therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Butalbital with Montelukast?
MediHelp rates the interaction as minor. Butalbital and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate with enzyme-inducing properties and may lower montelukast exposure with repeated use. Intermittent use is unlikely to matter, but frequent use may reduce efficacy.
How serious is the interaction between Butalbital and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma symptom control in patients using butalbital regularly. Adjust controller therapy if control worsens.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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