Drug interactions
Butalbital + Propofol
Severity: Moderate
Butalbital and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that adds to propofol-induced sedation and respiratory depression. Hypotension and prolonged recovery may occur.
What this interaction means in plain words
Butalbital and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor-mediated CNS depression.
What to do
Titrate propofol to effect with a reduced starting dose and monitor respiration and blood pressure. Avoid other concurrent sedatives where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Butalbital with Propofol?
MediHelp rates the interaction as moderate. Butalbital and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that adds to propofol-induced sedation and respiratory depression. Hypotension and prolonged recovery may occur.
How serious is the interaction between Butalbital and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with a reduced starting dose and monitor respiration and blood pressure. Avoid other concurrent sedatives where possible.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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