Drug interactions
Butorphanol + Chlorpromazine
Severity: Moderate
Butorphanol and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is strongly sedating and also lowers blood pressure, so with an opioid it can cause marked drowsiness, hypotension and respiratory depression.
What this interaction means in plain words
Butorphanol and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension through opioid activity plus antipsychotic dopamine, histamine and alpha-adrenergic blockade.
What to do
Start with reduced doses of both drugs and monitor sedation, blood pressure and respiration. Rise slowly from lying or sitting positions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Butorphanol with Chlorpromazine?
MediHelp rates the interaction as moderate. Butorphanol and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is strongly sedating and also lowers blood pressure, so with an opioid it can cause marked drowsiness, hypotension and respiratory depression.
How serious is the interaction between Butorphanol and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses of both drugs and monitor sedation, blood pressure and respiration. Rise slowly from lying or sitting positions.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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