Drug interactions
Butorphanol + Lisdexamfetamine
Severity: Minor
Butorphanol and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is a stimulant that may partly offset opioid-induced sedation, but it does not protect against respiratory depression. Stimulant cardiovascular effects may continue, so the net effect is unpredictable.
What this interaction means in plain words
Butorphanol and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Butorphanol belongs to Musculoskeletal; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
No routine dose change is required. Monitor sedation, respiratory rate and blood pressure, and avoid relying on the stimulant to counter opioid effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Butorphanol with Lisdexamfetamine?
MediHelp rates the interaction as minor. Butorphanol and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lisdexamfetamine is a stimulant that may partly offset opioid-induced sedation, but it does not protect against respiratory depression. Stimulant cardiovascular effects may continue, so the net effect is unpredictable.
How serious is the interaction between Butorphanol and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor sedation, respiratory rate and blood pressure, and avoid relying on the stimulant to counter opioid effects.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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