Drug interactions
Butorphanol + Metoclopramide
Severity: Moderate
Butorphanol and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butorphanol slows gastrointestinal motility, which can counteract metoclopramide, and both drugs contribute to sedation. Combined use can lead to excess drowsiness.
What this interaction means in plain words
Butorphanol and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Opioid-mediated reduction in gut motility and additive CNS depression.
What to do
Monitor for sedation and diminished prokinetic effect. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Metoclopramide?
MediHelp rates the interaction as moderate. Butorphanol and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butorphanol slows gastrointestinal motility, which can counteract metoclopramide, and both drugs contribute to sedation. Combined use can lead to excess drowsiness.
How serious is the interaction between Butorphanol and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and diminished prokinetic effect. Use the lowest effective doses.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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