Drug interactions
Cabazitaxel + Crizotinib
Severity: Moderate
Cabazitaxel and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may increase cabazitaxel exposure, raising the risk of neutropenia and gastrointestinal toxicity.
What this interaction means in plain words
Cabazitaxel and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing cabazitaxel metabolism.
What to do
Monitor blood counts and gastrointestinal toxicity closely, and reduce cabazitaxel dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Cabazitaxel with Crizotinib?
MediHelp rates the interaction as moderate. Cabazitaxel and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and may increase cabazitaxel exposure, raising the risk of neutropenia and gastrointestinal toxicity.
How serious is the interaction between Cabazitaxel and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and gastrointestinal toxicity closely, and reduce cabazitaxel dose if adverse effects occur.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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