Drug interactions
Cabazitaxel + Darunavir
Severity: Major
Cabazitaxel and Darunavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise cabazitaxel levels. This increases the risk of severe neutropenia and gastrointestinal toxicity.
What this interaction means in plain words
Cabazitaxel and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated cabazitaxel clearance by darunavir and its booster.
What to do
Avoid coadministration. If it cannot be avoided, consider a cabazitaxel dose reduction and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cabazitaxel
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Cabazitaxel with Darunavir?
MediHelp rates the interaction as major. Cabazitaxel and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise cabazitaxel levels. This increases the risk of severe neutropenia and gastrointestinal toxicity.
How serious is the interaction between Cabazitaxel and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. If it cannot be avoided, consider a cabazitaxel dose reduction and monitor blood counts closely.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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