Drug interactions
Cabazitaxel + Dronedarone
Severity: Moderate
Cabazitaxel and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may increase cabazitaxel exposure, increasing the risk of neutropenia and other toxicities.
What this interaction means in plain words
Cabazitaxel and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4, the main route of cabazitaxel clearance.
What to do
Monitor neutrophil counts closely and consider reducing the cabazitaxel dose or using an alternative antiarrhythmic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Dronedarone?
MediHelp rates the interaction as moderate. Cabazitaxel and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone may increase cabazitaxel exposure, increasing the risk of neutropenia and other toxicities.
How serious is the interaction between Cabazitaxel and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts closely and consider reducing the cabazitaxel dose or using an alternative antiarrhythmic.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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