Drug interactions
Cabazitaxel + Etravirine
Severity: Moderate
Cabazitaxel and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine induces CYP3A4 and may lower cabazitaxel concentrations, potentially reducing antitumor efficacy. Induction is weaker than with rifampicin or carbamazepine.
What this interaction means in plain words
Cabazitaxel and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4, accelerating cabazitaxel metabolism.
What to do
Monitor for reduced treatment response; prefer an antiretroviral without CYP3A4 induction if practical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Cabazitaxel with Etravirine?
MediHelp rates the interaction as moderate. Cabazitaxel and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine induces CYP3A4 and may lower cabazitaxel concentrations, potentially reducing antitumor efficacy. Induction is weaker than with rifampicin or carbamazepine.
How serious is the interaction between Cabazitaxel and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced treatment response; prefer an antiretroviral without CYP3A4 induction if practical.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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