Drug interactions
Cabazitaxel + Fluconazole
Severity: Moderate
Cabazitaxel and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase cabazitaxel exposure, increasing the risk of neutropenia and other adverse effects. Cabazitaxel labeling advises avoiding strong CYP3A inhibitors and caution with moderate ones.
What this interaction means in plain words
Cabazitaxel and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 metabolism of cabazitaxel.
What to do
Monitor blood counts closely and consider an alternative antifungal if feasible. Reduce cabazitaxel dose or delay cycles if severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Fluconazole?
MediHelp rates the interaction as moderate. Cabazitaxel and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may increase cabazitaxel exposure, increasing the risk of neutropenia and other adverse effects. Cabazitaxel labeling advises avoiding strong CYP3A inhibitors and caution with moderate ones.
How serious is the interaction between Cabazitaxel and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider an alternative antifungal if feasible. Reduce cabazitaxel dose or delay cycles if severe neutropenia occurs.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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