Drug interactions
Cabazitaxel + Itraconazole
Severity: Major
Cabazitaxel and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises cabazitaxel exposure, which increases the risk of neutropenia, diarrhea and other serious toxicity of the taxane.
What this interaction means in plain words
Cabazitaxel and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated cabazitaxel metabolism.
What to do
Avoid strong CYP3A4 inhibitors with cabazitaxel. If unavoidable, reduce the cabazitaxel dose by about a quarter and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Itraconazole?
MediHelp rates the interaction as major. Cabazitaxel and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole raises cabazitaxel exposure, which increases the risk of neutropenia, diarrhea and other serious toxicity of the taxane.
How serious is the interaction between Cabazitaxel and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors with cabazitaxel. If unavoidable, reduce the cabazitaxel dose by about a quarter and monitor blood counts closely.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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