Drug interactions
Cabazitaxel + Trastuzumab deruxtecan
Severity: Moderate
Cabazitaxel and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause myelosuppression, so combined use may increase the risk and severity of neutropenia and infection. No pharmacokinetic interaction is established.
What this interaction means in plain words
Cabazitaxel and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive pharmacodynamic bone marrow suppression.
What to do
Monitor complete blood counts regularly and watch for fever or infection. Dose-modify or delay per neutropenia guidance, using growth factor support as appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Cabazitaxel with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Cabazitaxel and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause myelosuppression, so combined use may increase the risk and severity of neutropenia and infection. No pharmacokinetic interaction is established.
How serious is the interaction between Cabazitaxel and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for fever or infection. Dose-modify or delay per neutropenia guidance, using growth factor support as appropriate.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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