Drug interactions
Cabazitaxel + Voriconazole
Severity: Major
Cabazitaxel and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may markedly raise cabazitaxel exposure, increasing risk of severe neutropenia and gastrointestinal toxicity.
What this interaction means in plain words
Cabazitaxel and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, the main route of cabazitaxel clearance.
What to do
Avoid strong CYP3A4 inhibitors with cabazitaxel. If unavoidable, consider a cabazitaxel dose reduction and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Voriconazole?
MediHelp rates the interaction as major. Cabazitaxel and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole may markedly raise cabazitaxel exposure, increasing risk of severe neutropenia and gastrointestinal toxicity.
How serious is the interaction between Cabazitaxel and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inhibitors with cabazitaxel. If unavoidable, consider a cabazitaxel dose reduction and monitor blood counts closely.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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